Gluten Sensitivity and Celiac Disease: 30 of the Most Interesting Scientific Journal Summaries (Continued)

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Iltanen S, Collin P, Korpela M, Holm K, Partanen J, Polvi A, Mäki M.
Institute of Medical Technology, University of Tampere, Finland

It is known that many autoimmune diseases occur concomitantly with celiac disease. The study investigated the occurrence of CD and small bowel mucosal inflammation in patients with primary Sjögren’s syndrome. The findings of the study show a close association between Sjögren’s syndrome and CD. Even among nonceliac patients with primary Sjögren’s syndrome an ongoing inflammation is often present in the small bowel.

17. Small-bowel mucosal inflammation in reticulum or gliadin antibody-positive patients without villous atrophy.

Scandinavian Journal of Gastroenterology 1998 September; 33(9):944-9
Kaukinen K, Collin P, Holm K, Karvonen AL, Pikkarainen P, Mäki M.
Department of Medicine and Pediatrics, Tampere University Hospital, Medical School and Institute of Medical Technology, University of Tampere, Finland.

The study investigated with the individuals with positive CD antibodies may not have small bowel villous atrophy. This study demonstrated that a large number of patients may have normal villous architecture, although they are positive for gliadin or other types of associated antibodies.
Prevalence of celiac disease autoantibodies in patients with systemic lupus erythematosus.


Rensch MJ, Szyjkowski R, Shaffer RT, Fink S, Kopecky C, Grissmer L, Enzenhauer R, Kadakia S
Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas, USA.

Systemic lupus erythematosus has been associated with false positive autoantibodies. An increased prevalence of autoantibodies are found in CD and systemic lupus erythematosus, which share the human lymphocyte HLA-B8 and HLA-DR3 histocompatibility antigens. The conclusion of the study is that the presence of false positive autoantibodies in patients with lupus is very common. Although this article suggested that there was not an association between CD and lupus, the office of this health letter believed that this is a misinterpretation of the facts simply because these authors had no evidence not to suggest that there is either a direct or indirect relationship between gliadin antibodies and lupus, as it is known that many immune and neurologic conditions are related to gliadin antibodies.

19. Thyroid and celiac disease: Clinical, serological, and echographic study.

American journal of gastroenterology 1998 June; 93(6):976-9
Velluzzi F, Caradonna A, Boy MF, Pinna MA, Cabula R, Lai MA, Piras E, Corda G, Mossa P, Atzeni F, Loviselli A, Usai P, Mariotti S.

Department of endocrinology, Institute of Internal Medicine, University of Cagliari, Italy.

This study sought to reevaluate the prevalence of thyroid dysfunction and autoimmunity in those with celiac disease. The conclusion of the article was that there is an elevated prevalence of clinical and subclinical autoimmunity in CD patients, particularly those displaying the DQB1 genotype. This finding could be related to a particular genetic background of the population of the study (Sardinian)

20. Detecting Celiac disease in your patients.

American Family Association 1998 March 1; 57(5):1023-34, 1039-41
Pruessner HT.
University of Texas Medical School, Houston, USA

The study reviews the known evidence that CD is a genetic and neurologically mediated small bowel enteropathy (disease that causes malabsorption). Immune inflammatory response to gluten causes damage not only to the gut but to many other tissues, and the condition is frequently undiagnosed due to its wide range of nonintestinal symptoms. The age of onset ranges from infancy to old age and may involve the skin, the blood system, the musculoskeletal system, mucosal system, dental, psychological, and neurological systems. Untreated patients have an increased incidence of osteoporosis and intestinal lymphoma. Fortunately, excellent diagnostic screening tests are now available.

21. Osteomalacia secondary to celiac disease, primary hypoparathyroidism, and Graves’ disease.

American Journal of Medical Science 1998 February; 315(2):139-6
Gannage MH, Abikaram G, Nasr F, Awada H.
Division of Endocrinology, Hotel Dieu de France Hospital, Beirut, Lebanon

Primary hypothyroidism is seldom associated with other autoimmune diseases. The presence of normal blood calcium, however, in primary hyperparathyroidism should prompt the physician to look for vitamin D deficiency. This article emphasizes the need to rule out intestinal malabsorption in the case of normocalcemic (normal blood calcium) hyperparathyroidism.

22. Celiac disease as a cause of chronic pelvic pain, dysmenorrhea, and pelvic dyspareunia.

Obstet Gynecol 2002 May; 99(5Pt 2):937-9
Porpora MG, Picarelli A, Prosperi Porta R, Di Tola M, D’elia C, Cosmi EV
Second Institute of Gynecology and Obstetrics, University of Rome "La Sapienza", Rome, Italy.

CD may be subclinical and difficult to diagnose in adults. It has been associated with infertility and miscarriage. The conclusion of this article is that CD should be considered in women presenting with unexplained chronic pelvic pain, dysmenorrhea, and deep dyspareunia.

23. Celiac disease and Williams syndrome.

Journal of Medical Genetics 2001 November; 38(11):767-8
Giannotti A, Tiberio G, Castro M, Virgilii F, Colistro F, Ferretti F, Digilio MC, Gambarara M, Dallapiccola B
Servizio Di Genetica Medica, Ospedale Bambino Gesu IRCCS, Piazza S Ofrio 4, 00165 Rome, Italy

Piazza S. Onofrio 4, 00165, Rome, Italy.

CD has been reported in several patients affected with chromosomal disorders including Down’s syndrome and Turner’s syndrome as well as Williams syndrome. The conclusion of the study suggests that the prevalence of CD in Williams syndrome patients is higher than in the general population and is comparable to the higher levels reported in those with Down’s syndrome and Turner’s syndrome. Therefore, antibody antigliadins of the IgA type as well as endomysium antibodies are recommended in patients with Williams syndrome.

24. Sporadic cerebellar ataxia associated with gluten sensitivity

Brain 2001 May; 124 (Pt 5): 1013-9.
Burks K, Bosch S, Muller CA, Melms A, Zuhlke S, Stern M, Besenthal I, Skalej M, Ruck P, Ferber S, Klockgether T, Dichgans J.
Department of Neurology, University of Tubingen, Germany

A group of patients with sporadic cerebellar ataxia were tested for antigliadin and antiendomysium antibodies. The clinical neurological syndrome was dominated by progressive cerebellar ataxia with ataxia of stance and gait, dysarthria, limb ataxia, oculomotor abnormalities, spontaneous nystagmus, saccade slowing, and other symptoms are included. The study concluded that sporadic ataxia may be associated with positive antibodies against gliadin. They also recognize that the mucosal pathology does not represent an obligatory condition of ataxia with gluten sensitivity. The fact that the disease is strongly associated with same HLA haplotypes found in CD not only demonstrates celiac disease and ataxia with gluten sensitivity to be part of the same disease entity but supports the hypothesis of an immunological pathogenesis of cerebellar degeneration.

25. Vitamin B12 deficiency in untreated CD

American Journal of Gastroenterology 2001 Mar; 96 (3:745-50)
Dahele A, Ghosh S
Department of Medical Sciences, University of Edinburgh, Western General Hospital, Scotland

The objective of the study was to discuss the fact that iron and folate malabsorption are common in untreated CD as the proximal small intestine is mostly affected. The conclusion of the study is contrary to what is popularly known that in fact B12 deficiency is common in untreated celiac disease and concentration should be measured routinely before hematinic replacement. Vitamin B12 concentrations normalize on a gluten-free diet alone, but symptomatic patients may require supplementation.

26. Celiac Sprue; another autoimmune syndrome associated with hepatitis C.

American Journal of Gastroenterology 2001 January; 96 (1:138-45)
Fine KD, Ogunji F, Saloum Y, Beharry S, Crippin J, Weinstein J.
The Intestinal Health Institute, Dallas, Texas, USA.

During this study, the investigator sought to test our hypothesis that hepatitis C also may predispose to CD because it can trigger autoimmune reactions. The result of the study showed that there was a statistically significantly higher prevalence of antigliadin antibodies in all groups of patients with liver disease compared with GI controls and normal controls. Because hepatitis C is much more frequently encountered than autoimmune liver disease, hepatitis C appears to be the most common hepatic diseases associated with the development of celiac sprue.

27. IgG subclass profile with serum antigliadin antibodies and antibody-dependent cell-mediated cytotoxicity in young children with CD.

Scandinavian Journal of Immunology 2001 January; 53 (1:92-8)
Saalman R, Dahlgren UI, Fallstrom SP, Hanson LA, Ahlstedt S, Wold AE.
Department of Clinical Immunology, Goteborg University, Goteborg, Sweden

Sera from children with active CD were found to efficiently induce antibody-dependent cell-mediated toxicity of gliadin-coated cells. Children with untreated celiac disease had high antigliadin antibody activities of all four IgG subclasses. However, they had a particularly high proportion of IgG1 antigliadin antibodies. The results of the study suggest that gliadin-specific antibodies of predominantly the IgG1 subclass mediate tissue-damaging immune reactions like ADCC (antibody-dependent cell-mediated cytoxicity) and thus may contribute to the disease process of celiac disease.

28. A high frequency of CD among children with neurological disorders.

European Journal of Neurology 2000 November; 7 (6:707-11)
Salur L, Uibo O, Talvik I, Juscus I, Metsküla K, Talvik T, Uibo R
Department of Immunology, University of Tartu, Tartu, Estonia.

The study explored antigliadin antibodies and antireticulin antibody tests as screening for CD in 206 children with neurological disorders. The conclusion of the study was that CD occurs more frequently among children with neurological disorders. In the study, they were able to demonstrate using indirect immunofluorescence testing that the weak presence of autoantibodies against the brain tissue in CD and AGA-positive patients.

29. Serologic markers of untreated CD in Libyan children: Antigliadin, antitransglutaminase, antiendomysial, and anticalreticulin antibody

Journal of Pediatric Gastroenterology and Nutrition 2001 September; 33 (3:276-82)
Ashabani A, Errabtea H, Shapan A, Tuckova L, Tlaskalova-Hogenova H,
Department of Immunology and Gnotobiology
Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic

There is also the study, which looked at the incidence of CD in Libya demonstrated that clinical symptoms at presentation were weight loss in 82%, abdominal distension in 61.5%, diarrhea or steatorrhea in 59%, pallor in 41%, abdominal pain in 20.5%, constipation at 50%, vomiting at 10%, and short stature at 7.7%. Mostly symptoms disappeared after introduction of a gluten-free diet. The conclusions were that the authors stressed the importance of serologic testing not only for screening but also for conformation of CD.

30. Etiologic aspects of chronic urticaria

Inc J Dermatology 1998 July; 37 (7) 515-9
Liutu M, Kalimo K, Uksila J, Kalimo H
Department of Dermatology, Medical Microbiology and Pathology, University of Turku, Finland

Urticaria is a common disease that is always a challenge to dermatologists due to its invasive etiology. 170 chronic urticaria patients were studied. The results of the study showed that the pathologic findings were seen in 92% of patients that were consistent with concomitant disease that suggest autoimmune reactivity in some patients. 55 of these patients had dyspeptic symptoms. H. Pylori IgG antibodies were found in 40 out of 107 patients. Active gastritis was verified by esophagogastroduodenoscopy in 30 out of 32 patients with positive H. pylori test. The conclusions of the study suggested abnormal immunological activation detected in those with chronic urticaria. Inflammation in the GI tract caused by H. pylori may have an important role in the etiology of chronic urticaria.

Copyright American Health Gastroenterology 2001


One Response to “Gluten Sensitivity and Celiac Disease: 30 of the Most Interesting Scientific Journal Summaries (Continued)”

  1. Gluten Sensitivity and Celiac Disease: 30 of the Most Interesting Scientific Journal Summaries | Healing Base on December 14th, 2011 00:23

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